Jie Jack Li
Dr. Li taught organic chemistry for three years as an
assistant professor of in China, an experience sowed the seeds his
passion for teaching. After earning his Ph.D. in organic chemistry
in 1995 at Indiana University, he carried out his postdoctoral
training at MIT. He then worked as a medicinal chemist for fifteen
years at Pfizer and Bristol-Myers Squibb, respectively. Although
primarily an industrial chemist, Dr. Li carried out many scholarly
activities during this period. In addition to being an inventor of
nine patents, he published 24 research articles, 36 reviews, and 17
books with topics ranging from organic chemistry, to medicinal
chemistry and history of drug discovery.
At USF, he teaches Organic Chemistry and History of Drug
Discovery. His current research interests are in two areas: (a)
Organic Chemistry: Development of synthetic methodology on the C-H
activation of heterocycles, which are of paramount importance to
drug discovery; and (b) Medicinal Chemistry: The current focuses
are to discover novel anti-diabetic drugs by inhibiting the PH
domain leucine-rich repeat protein phosphatase (PHLPP) in
collaboration with Prof. Alexandra C. Newton at UCSD and to
discover new anti-cancer drugs by targeting both novel and proven
mechanisms of action such as the hedgehog signaling pathway.
Postdoctoral Fellow, MIT
Ph.D., Indiana University
- Book, Li, J. J.; Corey, E. J.,
Eds.; Drug Discovery: Practices, Processes, and
Perspectives, Wiley: Hoboken, NJ, 2013.
- Patent, Li, J.; Robl, J. A.; Li, J. J.; Kennedy, L. J.; Wang, H.;
Li, J. J.; Qian, X.; Deshpande, R. P.; Kolla, L. R.; Cann, R. O.;
Wei, C.; Galella, M. Triazolopyridine 11-Beta Hydroxysteroid
Dehydrogenase Type I Inhibitors. US Patent 8,119,658
- Review, Li, J. J.; Johnson, A. R. Selective MMP13 Inhibitors,
in Medicinal Research Review2011,
- Book, Li, J. J. Name Reactions, A Collection of Detailed
Reaction Mechanisms, Fourth Edition, Springer: Heidelberg,
- Article, Li, J. J.; Yue, W.-S.; Ortwine, D. F.; Johnson, A. R.;
Man, C.-F.; Baragi, V.; Kilgore, K.; Dyer, R. D.; Han, H.-K.
Quinazolinones as Specific and Orally Active MMP-13 Inhibitors
for the Treatment of Osteoarthritis, in J. Med. Chem.
2008, 51, 835-841.